Dopamine is a neurotransmitter that binds to a specific type of GPCR.

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Dopamine is a neurotransmitter that binds to a specific type of GPCR.

Dopamine is a neurotransmitter that binds to a specific type of GPCR. Let’s say that one dopamine molecule can activate 20 G-proteins. In the absence of Ca2+ entry, activated adenylyl cyclase synthesizes 200 cAMP molecules. Two cAMP molecules are required to activate PKA and each molecule of PKA can phosphorylate 200 proteins. If 8 dopamine molecules bind to receptors, how many protein molecules can be phosphorylated? Assume that there are loads of adenylyl cyclase and PKA molecules (they are not rate limiting).

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