The nurse knows that treatment with pyrimethamine must be stopped if the client exhibits which ...

Correct Answer: 1,2
Rationale 1: Pyrimethamine can stimulate the CNS and cause seizures.
Rationale 2: Serious adverse effects such as folic acid deficiency, megaloblastic anemia, pancytopenia, thrombocytopenia, and leukopenia may occur.
Rationale 3: Nausea is a common adverse effect and would not require the drug to be discontinued.
Rationale 4: Vomiting is a common adverse effect and would not require the drug to be discontinued.
Rationale 5: Anorexia is a common adverse effect and would not require the drug to be discontinued.
Global Rationale: Pyrimethamine can stimulate the CNS and cause seizures. Serious adverse effects such as folic acid deficiency, megaloblastic anemia, pancytopenia, thrombocytopenia, and leucopenia may occur. Nausea, vomiting, and anorexia are common adverse effects and would not require the drug to be discontinued.