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Home Q & A Board Biology-Related Homework Help Medicine
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18ryanmandich 18ryanmandich
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6 years ago
A patient is being treated with amphotericin B Abelcet for a systemic fungal infection. After several weeks of therapy, the provider orders flucytosine Ancobon in addition to the amphote-ricin.
 
  The nurse understands that the rationale for this combination is that it: a. broadens the antifungal spectrum.
  b. improves the effectiveness of the ampho-tericin B.
  c. lowers the dose of amphotericin B and reduces toxicity.
  d. treats fungal central nervous system (CNS) infection.
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#1
6 years ago
C
Amphotericin potentiates the antifungal actions of flucytosine, and combining flucytosine with low-dose amphotericin can produce antifungal effects equivalent to those of high-dose amphote-ricin. By allowing a reduced dose of amphotericin, the combination also reduces the risk of am-photericin-induced toxicity. Flucytosine does not affect the effectiveness of amphotericin. The combination does not broaden the antifungal spectrum or alter the ability to treat CNS infections.
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