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Dextor Dextor
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11 years ago
If a person with a pericentric inversion is phenotypically normal why do they often have abnormal children? 
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A year ago
Pericentric inversion is a type of chromosomal rearrangement that occurs when a segment of the chromosome is inverted with respect to the centromere. Inversions are balanced rearrangements of chromosomes, and the vast majority of paracentric inversions seem to be harmless1. However, a few cases of abnormal offspring due to classic recombination of inversion have been described. The risk of having a phenotypically abnormal child for carriers of paracentric inversions due to the production of unbalanced gametes resulting from recombination during meiotic crossover has been thought to be low.

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