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barry barry
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Posts: 11630
13 years ago
One type of bacteria, called gram-negative bacteria, has a pyrogen molecule that is part of its membrane structure. This endogenous pyrogen is released when the cell is destroyed by the immune system. Why would a severe gram-negative bacterial infection be particularly dangerous to a patient?
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Valued Member
13 years ago
Large numbers of gram-negative bacteria would stimulate an immune response, leading to the destruction of the microorganisms. The problem is that by destroying large numbers of these bacteria, large amounts of the endogenous pyrogen are released all at once. This can cause a dangerous spike in body temperature.
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