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biostudent92 biostudent92
wrote...
9 years ago
Cystic fibrosis is a recessive disease that is caused by the CFTR gene. Interestingly, people with CF are resistant to cholera. Would cholera resistance be considered dominant or recessive?

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Answer rejected by topic starter
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Staff Member
Educator
9 years ago
Dominant
Mastering in Nutritional Biology
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Cynthia P. Author
wrote...
9 years ago
Dominant

Why?
Answer rejected by topic starter
wrote...
Staff Member
Educator
9 years ago
It doesn't ask why.

Quote
When two populations of any sexual organism are separated and kept isolated from each other, the frequencies of deleterious mutations in the two populations will differ over time, by genetic drift. It is highly unlikely, however, that the same deleterious mutations will be prevalent in both populations after a long period of separation. Since loss-of-function mutations tend to be recessive (given that dominant mutations of this type generally prevent the organism from reproducing and thereby passing the gene on to the next generation), the result of any cross between the two populations will be fitter than the parent.

This article deals with the specific case of fitness overdominance, where the fitness advantage of the cross is caused by being heterozygous at one specific locus alone.
Source  http://en.wikipedia.org/wiki/Heterozygote_advantage
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