Consider a chromosome with ordered loci A (A/a), B (B/b), C (C/c), D (D/d), and E (E/e) where the ...

Consider a chromosome with ordered loci A (A/a), B (B/b), C (C/c), D (D/d), and E (E/e) where the letters in the parentheses indicate the alleles at loci.
 
  On a chromosome in which A, C, D, and E are coupling, a new allele arises at the locus B. This new allele B, has a negative effect on fitness. As a result, we would expect:
  a. the genetic variation at neighboring loci to decrease.
  b. the alleles A, C, D, and E may be lost due to background selection.
  c. the alleles A, C, D, and E may be lost due to genetic hitchhiking.
  d. A and B.
  e. All of the above.