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adrianfebrianya adrianfebrianya
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6 years ago
How is the control of gene expression different between methylation of histone proteins and direct methylation of DNA?
 
  What will be an ideal response?
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6 years ago
Methylation of histone proteins changes accessibility of genes. It tightens the chromatin so that promoters are not accessible to activate transcription. Direct methylation of DNA also suppresses gene expression, but in a way that is often more permanent than histone modification. Once a particular nucleotide has become methylated in a cell's DNA, it will usually stay methylated in all of the cell's
descendants.
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