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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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littlescientist littlescientist
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6 years ago
In the genetic code, 61 of the codons specify amino acids and three codons are stop codons.
 
  However, according to the wobble hypothesis, a minimum of 31 tRNAs (excluding the initiator) are required to recognize 61 codons. What is the wobble hypothesis? Include in your answer the allowed base pairing scheme between codon and anticodon for the base inosine in the first position of the anticodon.
 
  What will be an ideal response?
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6 years ago
Ans: The wobble hypothesis states that the pairing between codon and anticodon in the first two codon positions always follows normal pairing rules but that additional base pairing is allowed to occur in the third codon position because the anticodon loop is flexible, usually involving G-U base pairs. Inosine in the first position of the anticodon can pair with A, C or U in the third position of the codon.
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