The oxidation of the Hb molecule's iron ions to the ferric state (Fe3+) results in which of the fol-lowing?
1. Form of anemia called sickle cell anemia
2. Formation of methemoglobin (metHb)
3. Inability of metHb to bind with O2
a. 1 and 2 only
b. 1 and 3 only
c. 2 and 3 only
d. 1, 2, and 3
Q. 2 Which of the following is true regarding fetal hemoglobin (HbF)?
a. It has a reduced level of 2,3-DPG.
b. It is replaced in the first month of life.
c. It delivers more O2 to tissues at low PaO2 than normal Hb.
d. It has a higher P50 than normal Hb.
Q. 3 Which of the following increases the affinity of Hb for O2? 1. Decreased 2,3-DPG 2. Decreased PCO2 3. Increased pH 4. Increased temperature
a. 1, 2, and 3 only
b. 1, 2, and 4 only
c. 3 and 4 only
d. 3 and 4 only
Q. 4 The affinity of Hb for carbon monoxide (CO) is approximately how many times greater than its affinity for O2?
a. 10 to 50 times greater
b. 50 to 90 times greater
c. 100 to 190 times greater
d. 200 or greater
Q. 5 In which of the following conditions will erythrocyte concentration of 2,3-DPG be decreased?
a. Anemia
b. Banked blood
c. High pH
d. Hypoxemia
Q. 6 According to the Bohr effect, when the pH drops, what happens? 1. The affinity of Hb for O2 decreases. 2. The Hb saturation for a given PO2 falls. 3. The Hb saturation for a given PO2 rises.
a. 1 and 2 only
b. 2 only
c. 2 and 3 only
d. 1, 2, and 3
Q. 7 What happens when the temperature of the blood rises? 1. The Hb saturation for a given PO2 falls. 2. The HbO2 curve shifts to the right. 3. The affinity of Hb for O2 increases.
a. 1 and 2 only
b. 1 and 3 only
c. 2 only
d. 1, 2, and 3
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