What is the difference between endocrine and exocrine glands?

What is the difference between endocrine and exocrine glands?
  a. Endocrine glands are discrete structures, while exocrine glands may be specialized cells in
  other tissues.
  b. Exocrine glands produce hormones, while endocrine glands do not.
  c. Endocrine glands only affect cells in the immediate area, while exocrine glands do not.
  d. Endocrine glands secrete into the interstitial fluid, while exocrine glands release secretions
  into ducts.
  e. Exocrine glands secrete neurohormones, while endocrine glands do not.

Question 2

Hormones regulate their effects on cells by all of the following EXCEPT:a.
   negative feedback.
  b. receptor up-regulation.
  c. receptor down-regulation.
  d. signal transduction.
  e. metamorphosis.