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A client has been started on diltiazem (Cardizem), a substrate of the cytochrome CYP3A4 isoenzyme ...

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A client has been started on diltiazem (Cardizem), a substrate of the cytochrome CYP3A4 isoenzyme ...

A client has been started on diltiazem (Cardizem), a substrate of the cytochrome CYP3A4 isoenzyme system. The client also takes phenobarbital, an inducer of the CYP3A4 isoenzyme system, for seizures. What does the nurse recognize about diltiazem?
1. It will not be able to cross the bloodbrain barrier (BBB).
2. It will be metabolized by the kidneys.
3. It might be inactivated at a faster rate than normal.
4. It might be excreted at a slower rate.

Textbook

Pharmacology: Connections to Nursing Practice

Edition: 4^th

Authors: Adams, Urban

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