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2 weeks ago
A patient is being treated with amphotericin B for a fungal infection of the urinary tract. What is the action of amphotericin B?
A)It binds to ergosterol and forms holes in the membrane.
B)It binds to an enzyme required for synthesis of ergosterol.
C)It disrupts the fungal cell walls rather than the cell membrane.
D)It inhibits glucan synthetase required for glucan synthesis.
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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Amphotericin B binds to ergosterol and forms holes in the membrane, causing leakage of fungal cell contents and lysis of the cell. The azole drugs bind to an enzyme that is required for synthesis of ergosterol. This action causes production of a defective cell membrane, which allows leakage of intracellular contents and destruction of the cell. Echinocandins disrupt fungal cell walls rather than fungal cell membranes. They inhibit glycan synthetase, an enzyme required for synthesis of glucan.

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