Explain why a cell needs both type I and type II topoisomerases.

colleen

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12 years ago

Explain why a cell needs both type I and type II topoisomerases.

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chemb

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12 years ago

Prokaryotes use topoisomerase II (DNA gyrase) to negatively supercoil DNA, which is critical for packaging large quantities of DNA into a small volume. DNA gyrase also can work in the opposite way to unwind a supercoil by breaking both strands for DNA replication. Topoisomerase I instead makes only a break on one of the two DNA strands, and this nicking process unwinds a coiled region of DNA.

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