How do hypoxia cause inflammation?

Referring to following link, I would like to know on how hypoxia cause inflammation and what the purpose of inflammation is.

Does anyone have any suggestions?
Thanks in advance


https://www.frontiersin.org/articles/10.3389/fimmu.2017.00324/full

Inflammation and environmental oxygen levels are linked; inflammation is often accompanied by hypoxia, and hypoxia itself can cause inflammation (7). In patients, many different inflamed tissues have been shown to have lower than normal oxygen levels. In the GI tract, mice with experimental models of inflammatory bowel disease (IBD) have increased inflammation and decreased oxygen levels in their colonic tissues (8), which corresponds with pathology observed in IBD patients (9). Examining the role of hypoxia in modulating epithelial cell and immune cell responses has been an area of active investigation in the design of new therapeutics for treating IBD (10).