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MZ Mai MZ Mai
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The pedigrees below are for a dominant disease where individuals with the dominant disease allele (D) are affected. Individuals that were alive were also screened for a polymorphic DNA marker that has six alleles identified as P1, P2, P3, P4, P5, and P6.
a)In Family B, explain why the P1 marker cannot be assumed to be transmitted with the dominant 
allele given that there is no haplotype data for the first generation.
b)In Family A, how does the information regarding the haplotype of individuals in the first 
generation allow you to determine the allelic phase of the disease?
"Use Figure 5.15 in Chapter 5, page 169 from main title."
Textbook 

Genetic Analysis: An Integrated Approach


Edition: 3rd
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soniazhaisoniazhai
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More questions for this book are available here
a) In Family B, three of the affected individuals in generation III (III-1, III-3, and III-4) received the 
P1 allele along with the disease allele, whereas the other affected individual (III-6) received the P2 allele along with the disease allele. This shows that the disease allele can be associated with both the P1 and P2 alleles. However, definitive identification of the allelic phase is not possible with the information provided in the pedigree for Family B. It should not be assumed that the disease allele is associated with the P1 variant, even though (1) it is more prevalent and (2) individual III-5's haplotype likely resulted from a recombination event.

b) The P1 allele is carried with the disease allele because the affected maternal parent (I-2) 
transmits her P1D allele to her affected offspring (II-1). Furthermore, most of the offspring of individual II-1 that are affected also carry the P1 variant. This combined knowledge provided in the pedigree for Family A, supports the conclusion that P1 marker allele is transmitted with the disease allele.

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