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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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Wellz999 Wellz999
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2 years ago
Many mutations in the bithorax gene are known, such as postbithorax, contrabithorax and bithoriaxoid.  Each mutation has a different effect on development of the reduced wing-like T3 appendage, the haltere.  None of these mutations occurs in the coding sequence of bithorax, instead, where are these mutations and how do they effect development?

▸ These mutations alter the slice sites for bithorax and affect the splicing of the bithorax mRNA.  Their different effects on development are cause by affects on alternative splicing.

▸ Each mutant alters a different codon within the bitorax gene, which affects the DNA-binding behavior of the bithorax protein.

▸ These mutations each effect silent sites and effect the stability of the bithorax mRNA.

▸ Bithorax is inhibited by zygotic genes from the mother and these mutations affect maternal genes.

▸ These mutations each effect a different enhancer(s) near the bithorax gene and the resulting misexpression of bithorax in each mutant causes patterning defects in the haltere.
Textbook 
Genetic Analysis: An Integrated Approach

Genetic Analysis: An Integrated Approach


Edition: 3rd
Authors:
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Hammadsyed14Hammadsyed14
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Wellz999 Author
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2 years ago
Good timing, thanks!
derya1234
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Yesterday
I appreciate what you did here, answered it right Smiling Face with Open Mouth
jodie1
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2 hours ago
Correct Slight Smile TY
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