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Anonymous Sandra Kay Vance
wrote...
3 months ago
Order: DTIC-Dome (dacarbazine) 250 mg/m2 IV for 5 days.
The label on the vial reads 500 mg, and the manufacturer's directions state to reconstitute with 9.9 mL of sterile water for injection, yielding a strength of 50 mg/mL, further dilute in 250 mL of D5W, and infuse over 60 minutes. Calculate the rate of flow in milliliters per hour for a client who weighs 82 kg and is 170 cm ta
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pie
wrote...
#1
3 months ago
To calculate the flow rate in milliliters per hour (mL/hr):

1. Dose Calculation: 
   - Dose = 250 mg/m²/day 
   - Body Surface Area (BSA) ≈ 2.0 m² (using weight 82 kg and height 170 cm). 
   - Total daily dose = 250 mg/m² × 2.0 m² = 500 mg/day.

2. Reconstitution: 
   - Reconstituted solution strength = 50 mg/mL. 
   - Volume required for 500 mg = 500 mg ÷ 50 mg/mL = 10 mL.

3. Dilution:
   - Further dilute in 250 mL of D5W. 
   - Total volume to infuse = 260 mL.

4. Flow Rate: 
   - Infuse over 60 minutes (1 hour). 
   - Flow rate = 260 mL ÷ 1 hour = 260 mL/hr.

Final Answer: 260 mL/hr.
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