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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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morgan795 morgan795
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9 years ago Edited: 9 years ago, morgan795
A hereditary disease is inherited as an autosomal recessive trait.
The wild-type allele of the disease gene produces a mature mRNA that is 1250 nucleotides (nt) long. Molecular analysis shows that the mRNA consists of four exons:

(Attachment Doc2.docx)

 A mother and father with two healthy children and two children with the disease have northern blot analysis performed in a medical genetics laboratory. The results of the northern blot for each family member are shown.



Based on your analysis, what is the most likely molecular abnormality causing the disease allele?
   A) A pre-mRNA spicing mutation causes a deletion of exon 1.
   B) A pre-mRNA spicing mutation causes a deletion of exon 2.
   C) A pre-mRNA spicing mutation causes a deletion of exon 3.
   D) A pre-mRNA spicing mutation causes a deletion of exon 4.

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egbernaregbernar
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9 years ago
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wrote...
#2
9 years ago
?
wrote...
#3
9 years ago
For Part A:

You match each trait's northern blot analysis to the numbers provided on the left, either 1250 and/or 1020. Pretty simple.

For Part B: 

I subtracted 1250 from 1020 and got 230. Referring to the table, is Exon 3.  Not sure if that is how you should really answer the question, but my answer was correct.
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