Determine the codon for each mutant

this one is super tough.  why the attachment?

Comes as part of the question, but I actually think it goes with a different problem.

Know how to work this one??

I never did this before, but it looks like fun so let's give it a try.

We are told the following:
A. Each amino acid substitution resulted from a single base substitution.
B. Mutant A has the codon UGG.

Let's start with Mutant A:
We know its codon sequence is UGG. Hence, the normal codon sequence will be only one base pair different. The only possibility that codes for serine and fits this rule is UCG.

Next, let's figure out Mutant B:
We are told that Mutant B codes for leucine. By looking at the protein translation chart, we know there are only 6 possibilities:   UUA UUG CUU CUC CUA CUG

However, we also know that Mutant B must be only one base substitution away from the normal protein and mutant A. The only codon sequence that fits is: UUG

Let's figure out Mutant E next:
We are told that Mutant E codes for valine. There are 4 possibilities from the protein translation chart: GUU GUC GUA GUG. Of these, only a single possibility is one base substitution away from Mutant B. That would be GUG.

Let's figure out Mutant D next:
Mutant D codes for glycine. The 4 possibilities are: GGU GGG GGA GGC. Of these, only a single possibility is one base substitution away from Mutant E. That would be GGG.

Finally, let's figure out Mutant C:
Mutant C codes for arginine. There are two possibilities that are one base substitution away from Mutant A and Mutant D. Those are CGG and AGG.  This is where I get "stuck" between choosing one mutation over the other without more information.

Hope this is correct.


 

What is the codon for the normal?

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Post Merge: 11 years ago

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And could you actually do a new chart for how it should look??


Normal : ?
Mutant A: ?
Mutant B: ?
Mutant C: ?
Mutant D: ?
Mutant E: ?

@selfstudy: I posted the answers to your question above (do a "refresh" on this thread if you don't see my post.)

Cheers!

Sorry, but it will not let me refresh!! Could you copy and past it into a new reply or direct message it to me?? Thanks!

@colleen  I was asking if he could put it in chart form..plus the normal codon wasn't given

Seriously...CHILL OUT

I believe Colleen was merely bemused by your inability to view my original post (as was I.)

And the codon sequence for the 'normal' amino acid was, indeed, listed in my original post.

Anyway, since you don't want to read or deal with the reasoning to the answers above, here they are in 'chart form',

Normal : UCG
Mutant A: UGG
Mutant B: UUG
Mutant C: AGG or CGG
Mutant D: GGG
Mutant E: GUG


Hope that helps.

I did read/deal with the post above...Just trying to make sure I was getting the right answer.

Thanks for helping though.