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UmiNoTriton95 UmiNoTriton95
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8 years ago
Lafora Disease and Tay Sachs Disease are characterized by abnormal storage disorders within the nueron cells resulting in a phenotype of rapid intellectual decline and siezures. But the difference is which cehimical is disroderd? While Lafora is caused by a plant like starch, which is dangerous for humans, Tay-Sachs is caused by a dangerous buildup of lipids in the nerves. Age of onset is different for disorders, while Tay-Sachs happens in infants, Lafora happens in preteen and teenage years. Both result in rapid decline of physical and mental function to the point of death within a few years after onset. I used to think Lafora is Alziehmers for Teens but because the biology is different and the decline in Lafora is much more rapid and severe and death happens much quicker than in Alziehmers, I changed my mind. Now I kind of see Lafora as Tay-Sachs for Teens? Is it biologically appropiate based on dangerous chemical buildup in nerve cells?
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wrote...
Educator
8 years ago
While the symptoms might be similar, the two disorders work differently. Therefore, I would suggest they're not the same. Mind you, this conclusion came after ten minutes of research.
UmiNoTriton95 Author
wrote...
8 years ago
To me comparing Lafora to Tay Sachs is like comparing Alexander Disease to Alziehmers in terms of biological causes.
wrote...
Staff Member
8 years ago
Tay Sachs - chromosome 15
Lafora  - chromosome 5
- Master of Science in Biology
- Bachelor of Science
UmiNoTriton95 Author
wrote...
8 years ago Edited: 8 years ago, UmiNoTriton95
Actually Lafora gene defects are on Chromosome 6. I nickname Lafora "Tay Sachs for Teens" in the same way this artcile calls Alexander Disease "Alziehmers for the developing brain" (http://www.ncbi.nlm.nih.gov/pubmed/10609673), it's a nickname for similar pathology.
wrote...
Educator
8 years ago
Similar pathologies but different cause, true.
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