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Home Q & A Board Biology-Related Homework Help Biochemistry
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13 years ago
What are the symptoms and causes of Cushing's disease? How do they compare and contrast with symptoms and causes of Addison's disease?
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13 years ago
Cushing's disease is hypercortisolism, which can arise from adrenal or pituitary tumors or exogenous administration of cortisol. Symptoms include gluconeogenesis and consequent hyperglycemia, tissue wasting (especially in the limbs) from breakdown of protein and fat, excess fat deposition in trunk and face, mood elevation followed by depression, and difficulty with learning and memory. Addison's disease, far less common, is hyposecretion of cortisol as well as other adrenal steroids. It is usually caused by autoimmune destruction. Symptoms include darkening of the skin due to effects of ACTH on melanocytes.
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13 years ago
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