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lexus3431 lexus3431
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12 years ago
What happens to pepsin activity as it reaches the small intestine?
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wrote...
12 years ago
The small intestine releases bicarbonate to buffer the acidic pH of pepsin. (pH in the stomach is 2 - very acidic).  So pepsin isn't actively involved in the digestive process in the small intestine.  It's job in the stomach is to digest proteins, in the small intestine, this job is done by trypsin which is made in the pancreas.
wrote...
12 years ago
Pepsin works best at a pH of 2.0. This is why it works very well in the acidic conditions of the stomach. In the small intestine, the pH is about 8.0, which is too high for Pepsin. Thus, it denatures in the small intestine.
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