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smmcmahon35 smmcmahon35
wrote...
11 years ago
Provide a molecular-level explanation why the amino acid sequence of HIV protease is changing over time more rapidly than typical sequences of eukaryotes or bacteria.
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wrote...
#1
11 years ago
Of all the discussions we can have about HIV, see what HIV/AIDS has done to the African children:check out,

http://youngheroes.org.sz

just stumbled on this site and was touched:
wrote...
#2
11 years ago
HIV uses an enzyme called reverse transcriptase (RT) to make its DNA.

This enzyme (fortunately for the virus, unfortunately for us) is extremely error-prone. It makes several mistakes that lead to mutations in the viral DNA. This in turn leads to constant changes in the proteins that get made from the DNA, including HIV protease, an enzyme that cleaves larger proteins into functional ones.  

There are certain parts of the DNA where the RT makes many more errors. These are called mutational hot spots.
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