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Smntnl Smntnl
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12 years ago
What is the difference between the S1 and S1' pockets of a protease?
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12 years ago
The nomenclature to describe the interaction of a substrate with a protease has been introduced in 1967 by Schechter and Berger and is now widely used in the literature. In this system, it is considered that the amino acid residues of the polypeptide substrate bind in enzyme subsites of the active site. By convention, these subsites on the protease are called S (for subsites) and the substrate amino acid residues are called P (for peptide). The amino acid residues of the N-terminal side of the scissile bond are numbered P3, P2, P1 and those residues of the C-terminal side are numbered P1', P2', P3'....The P1 or P1' residues are those residues located near the scissile bond. The substrate residues around the cleavage site can then be numbered up to P8. The subsites on the protease that complement the subtrate binding residues are numbered S3, S2, S1, S1', S2', S3'......
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