× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
New Topic  
oaslam oaslam
wrote...
Posts: 28
Rep: 0 0
12 years ago
Converted to morphine and crossed the BBB, it binds to the opiate receptor sites leading to inhibition of GABA which in turn leads to a flood of dopamine.

So the paramedics arrive with their neat little box kit of naloxone and the overdosing casualty wakes to consciousness (hopefully)

What exactly happens to all that morphine that's still flowing around?
Read 663 times
1 Reply

Related Topics

Replies
wrote...
12 years ago
IIRC (it's late), then Naloxone is a competitive antagonist with a high affinity for the opiate receptor. Basically. It fills up the overwhelming majority of the opiate receptors in the central nervous system.

Since those opiate receptors are occupied, an opiate, such as morphine, cannot provoke a physiological reaction. The site it needs is already occupied by a higher affinity molecule, which produces no reaction. So it sits there, inert, and is removed by the same body processes that would remove it if its effects weren't blocked.

Basically, the usefulness of naloxone is to block the effect of an overdosed opiate until the body can remove all of it.
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  793 People Browsing
(22:58:00) (170976): Hello,
(22:58:00) (170976): "prepare" caught my eye as potentially misspelled. spelldoc.co​m often helps me verify quickly.
(22:58:01) (170976): Best regards,
Show Emoticons
:):(;):P:D:|:O:?:nerd:8o:glasses::-):-(:-*O:-D>:-D:o):idea::important::help::error::warning::favorite:
Related Images
  
 555
  
 3039
  
 540
Your Opinion
Who's your favorite biologist?
Votes: 722