Discuss the influence of cholecystokinin (CCK) and secretin on the acinar cells of the pancreas.

Both cholecystokinin (CCK) and secretin are produced by the duodenum to target the acinar cells of the pancreas. Cholecystokinin (CCK) is produced by duodenal enteroendocrine cells in response to the presence of lipids and partially digested proteins in the duodenum. CCK acts on acinar cells to trigger the secretion of digestive enzymes and other proteins. Another stimulatory hormone is secretin, which is released by duodenal cells in response to acid and lipids in the duodenum. Secretin primarily triggers duct cells to secrete bicarbonate ions.