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txgalbiolclas txgalbiolclas
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11 years ago
The mode of action of penicillin is to prevent the peptide bridges that connect the NAM-NAG backbone of the peptidoglycan from forming. Would you recommend penicillin to treat an infection caused by a Gram-positive or a Gram-negative bacteria type of a bacteria? Explain the reasons for your choice in detail.
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wrote...
11 years ago
Penicillin can be used effectively against Gram positive bacteria.
Penicillin "attacks" peptidoglycan molecules on the membrane of bacteria.
In Gram + bacteria peptidoglycan makes up about 90% of their cell wall and it is in the outermost layer.Therefore penicillin can react with these peptidoglycan molecules.
On the other hand gram negative bacteria have peptidoglycan in their cell walls but that cell wall in NOT the outermost layer.Their cell wall is located between the plasma cell and an outer LPS layer.Therefore penicillin cannot react with the peptidoglycan molecules of Gram - cells.

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