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Home Q & A Board Biology-Related Homework Help Biochemistry
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rivs9 rivs9
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11 years ago
Assume that glyceraldehyde-phosphate dehydrogenase was inhibited with iodoacetic acid.  Which glycolytic intermediate would you expect to accumulate most rapidly, and why?
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11 years ago
Keep in mind that this step of the glycolytic pathway is reversible.

If we are going from glucose to pyruvate, the intermediate "Glyceraldehyde 3-Phosphate" would accumulate, as it is the substrate for the enzyme that is inhibited.

If we were going from pyruvate to Glucose, the intermediate "1,3-Bisphosphoglycerate" would accumulate.

Cheers!
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