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len5002 len5002
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11 years ago
Describe one example of a human disorder that is inherited and also describe the specific inheritance pattern.  For this example, pick disorders that result from mutations in DNA or chromosome number rather than examples such as a genetic tendency for a disorder such as cancer.

I'm not getting the inheritance pattern part of this mess. I'm not in college and haven't been in school for nearly a decade, so that doesn't help much either, lol.
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wrote...
11 years ago
Basically, they're asking for something like "the gene is recessive" or "the gene is sex-linked".  Here's a good example:

Red-green colorblindness is when a person can't distinguish between red and green.  It is caused by a recessive gene on the X chromosome.

How in depth do they want you to go?  Is that going to be enough, or would you have to explain what "recessive" means and what it means that it's on the X chromosome instead of one of the others?

This means that:

1.  Men only get one X chromosome.  They will express whatever gene is present on that one X chromosome, so if a man is colorblind, he has one colorblind X.  If he isn't, he has one good X.

2.  Women get two X chromosomes.  This means that if a woman has 2 normal X's, she has normal vision.  If she has 1 normal and 1 colorblind copy, she has normal vision.  She is only colorblind if she has two colorblind X's.

3.  This means that a woman who is colorblind will always have colorblind sons.  Sons get their Y from their father and their X from their mother, so it doesn't matter at all what their father's X is like--they get their mother's.  A woman who has normal vision but is a carrier of the colorblind gene (one normal and one colorblind copy) has a 1 in 2 chance of having a colorblind son.  A woman who has normal vision, and isn't a carrier, will always have sons with normal vision.

4.  A daughter can only become colorblind if her father is also colorblind, and her mother is either a carrier or is also colorblind.  If her father has normal vision, the daughter will always have normal vision (she will get at least one normal, dominant X from her father).

A few other ones that you could talk about:

Sickle cell anemia
Bombay phenotype
Cystic Fibrosis
Polydactyly
Huntington's Disease
wrote...
11 years ago
If the disorder is due to mutation in the dominant allele (A) than it's inheritance pattern will be that each individual in each generation will be sick besides those that have aa genotype. etc...
wrote...
11 years ago
look for a sex-linked disease. those are easiest
examples of some:
huntington's
down syndrome (trisomy)
klinefelter's
color-blindness
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