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Biomedgirl123 Biomedgirl123
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12 years ago
Hey, this is a practice question from one of my exams and I am having trouble answering it. Any help would be great! Slight Smile

Glucagon receptor is a membrane protein that regulates the level of glucose in blood. Glucagon interacts with glucagon receptors localized in the plasma membrane , which leads to conversion of glycogen to glucoase through a series of cellular processes. Glucagon can also associate with glucagon kinases that phosphorylates glucagon in the cytoplasm. A graduate student tried to test these interactions using yeast two-hybrid system. S/he was only successful in detecting the interaction between glucagon and the glucagon kinase. Explain why s/he failed to detect the interaction between glucagon and glucagon receptor. 
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12 years ago
The answer is sort of stated in the question, I think. The receptor is actually a G protein coupled receptor, which are known for activation of adenylate cyclase and increased levels of intracellular cAMP. In addition, following the activation of adenylate cyclase, the resulting cAMP acts as a second messenger by interacting with and regulating other proteins such as protein kinase A and cyclic nucleotide-gated ion channels. My guess is that glucagon doesn't interact directly with the receptor, because the receptor - once activated - relays the message over to glucagon kinases which then phosphorylates glucagon in the cytoplasm.
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