× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
New Topic  
willuhelp willuhelp
wrote...
Posts: 17
Rep: 0 0
10 years ago
I am not sure if I am understanding this slide correctly, but what I got thus far is that a KO mouse is generated by injecting the blastocyst with the heterozygous ES cells resulting in a chimeric individual which contains both wild type & heterozygous mutant cells. The blastocyst is then selected and injected into a surrogate female, where she creates chimeric offspring. Now I am confused when they mate chimeric mouse with wild type, what is the point of this? Also, what would result if a KO mouse was not incorporated, what would be the likely result and offspring? Thanks again for reading this and your responses.
 Attached file 
Thumbnail(s):
You must login or register to gain access to this attachment.
Read 836 times
1 Reply

Related Topics

Replies
wrote...
Staff Member
10 years ago
Now I am confused when they mate chimeric mouse with wild type, what is the point of this? Also, what would result if a KO mouse was not incorporated, what would be the likely result and offspring? Thanks again for reading this and your responses.

Isn't it to increase the likelihood of producing brown mice?
- Master of Science in Biology
- Bachelor of Science
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  867 People Browsing
Related Images
  
 1244
  
 7177
  
 7452
Your Opinion
Which is the best fuel for late night cramming?
Votes: 145