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ehd123 ehd123
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Posts: 778
11 years ago
 What is meant by positive negative selection? and how is it done?
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B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience


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wrote...
Staff Member
Educator
11 years ago
HI Ehd123, you mean in terms of genetics? I've included something that might help as an attachment. Let me know what happens.
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ehd123 Author
wrote...
Valued Member
11 years ago
Hey padre
Thank you for the article, but now it's not genetics... It's something got to do with techniques to select for cells  Confounded Face
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience


wrote...
Staff Member
Educator
11 years ago
Oh right! Then I remember doing this in immunology class.

It has to do with T cells as they mature, right?

In the thymus, the immature T cells (the thymocytes), must productively rearrange their TCR genes so they can express a functional TCR (αβ or γδ).

αβ TCR+ T cells need to commit to expressing either CD4 or CD8

They must survive positive selection, that is, it allows for “useful” T cells to be selected for and expanded in number. They must survive negative selection, this allows for “dangerous” T cells to be removed.

Here's what I used to learn it before Downwards Arrow
Source  http://www.bio.davidson.edu/Immunology/Flash/Main.html
Mastering in Nutritional Biology
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ehd123 Author
wrote...
Valued Member
11 years ago
Now I see where positive and negative came from  Sad Dummy

That was a great animation! Seen something similar for microarrays though *sound wise and all*

Thank you so much! Greatly appreciated  Slight Smile
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience


wrote...
Staff Member
Educator
11 years ago
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Mastering in Nutritional Biology
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