ICQs17,18

Click to edit Master title style Click to edit Master text styles Second level Third level Fourth level Fifth level Click to edit Master text styles Second level Third level Fourth level Fifth level To study cell fate in the cortex, one needs to be able identify a dividing cell early on, and then later determine its identity (what it has differentiated into). Tritiated thymidine is Incorporated into a dividing cell, and retained only in that cell Incorporated into a dividing cell this cell and its progeny will have the label Class 17 ICQs Neurons migrate to form cortical layers What does this experiment tell you (.5 pts) The superficial layers form first The deep layers form first The cells are committed to make a particular layer before they migrate The cells are not committed until after they migrate superficial deep Transplant precursor from E29 donor (early) to P1 host (late) 12.19 Cell transplanted after S phase Cell transplanted in S phase What does this experiment tell you The precursor cells are committed to their laminar fate The precursor cells are not always committed to their laminar fate Transplant precursor from P1 donor to E29 host Is this plasticity maintained over time Transplants go to 2/3 2/3 Host cells migrate to 5/6 Class 18 ICQ (3 pts for participation)