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Chapter 10 - The Endocrine System
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C h a p t e r
10
The Endocrine System
Homeostasis is preserved through
intercellular communication
The Endocrine System
The Endocrine System
Regulates long-term processes:
Growth
Development
Reproduction
Uses chemical messengers to relay information and instructions between cells
The Endocrine System
Endocrine Communication
Endocrine cells release chemicals (hormones) into the bloodstream
Alters metabolic activities of many tissues and organs simultaneously
The Endocrine System
Target Cells
Are specific cells that possess receptors needed to bind and “read” hormonal messages
Hormones
Stimulate synthesis of enzymes or structural proteins
Increase or decrease rate of synthesis
Turn existing enzyme or membrane channel “on” or “off”
The endocrine system
regulates physiological processes through the binding of hormones to receptors
The Endocrine System
Figure 10-1
The Endocrine System
Figure 10-1
The Structure of Hormones
Hormones can be divided into three groups
Amino acid derivatives
Peptide hormones
Lipid derivatives
Circulate freely or bound to transport proteins
Mechanisms of Hormone Action
Hormone Receptor
Is a protein molecule to which a particular molecule binds strongly
Responds to several different hormones
Different tissues have different combinations of receptors
Presence or absence of specific receptor determines hormonal sensitivity
Target Cells and Hormones
Figure 10-2
Mechanisms of Hormone Action
Hormones and Plasma Membrane Receptors
Catecholamines and peptide hormones:
Are not lipid soluble
Are unable to penetrate plasma membrane
Bind to receptor proteins at the outer surface of the plasma membrane (extracellular receptors)
Mechanisms of Hormone Action
Hormones and Plasma Membrane Receptors
Bind to receptors in plasma membrane
Cannot have direct effect on activities inside target cell
Use intracellular intermediary to exert effects:
First messenger:
leads to second messenger
may act as enzyme activator, inhibitor, or cofactor
results in change in rates of metabolic reactions
Mechanisms of Hormone Action
Important Second Messengers
Cyclic-AMP (cAMP):
Derivative of ATP
Cyclic-GMP (cGMP):
Derivative of GTP
Calcium ions
Mechanisms of Hormone Action
Hormones and Plasma Membrane Receptors
G Protein:
Enzyme complex coupled to membrane receptor
Involved in link between first messenger and second messenger
Binds GTP
Activated when hormone binds to receptor at membrane surface and changes concentration of second messenger cyclic-AMP (cAMP) within cell:
increased cAMP level accelerates metabolic activity within cell
Nonsteroidal Hormones
Figure 10-3a
Mechanisms of Hormone Action
Hormones and Intracellular Receptors
Alter rate of DNA transcription in nucleus:
Change patterns of protein synthesis
Directly affect metabolic activity and structure of target cell
Includes steroids and thyroid hormones
Steroids and Thyroid Hormones
Figure 10-3b
The Control of Endocrine Activity
Endocrine reflexes can be triggered by
Humoral stimuli:
Changes in composition of extracellular fluid
Hormonal stimuli:
Arrival or removal of specific hormone
Neural stimuli:
Arrival of neurotransmitters at neuroglandular junctions
Hypothalamic Control over Endocrine Function
Figure 10-4
The bilobed pituitary gland is an endocrine organ that releases nine peptide hormones
The Pituitary Gland
Also called hypophysis
Lies within sella turcica
Hangs inferior to hypothalamus
Connected by infundibulum
Pituitary Gland
Figure 10-5
The Hypophyseal Portal System
Figure 10-6
Pituitary Gland
Two Classes of Hypothalamic Regulatory Hormones
Releasing hormones (RH):
Stimulate synthesis and secretion of one or more hormones at anterior lobe
Inhibiting hormones (IH):
Prevent synthesis and secretion of hormones from the anterior lobe
Rate of secretion is controlled by negative feedback
Pituitary Gland
Anterior lobe (also called adenohypophysis)
Hormones “turn on” endocrine glands or support other organs
Feedback Control of Endocrine Secretion
Figure 10-7a
Feedback Control of Endocrine Secretion
Figure 10-7b
Figure 10-8
Pituitary Gland
Posterior lobe (also called neurohypophysis)
Contains unmyelinated axons of hypothalamic neurons
Supraoptic and paraventricular nuclei manufacture:
Antidiuretic hormone (ADH)
Oxytocin (OXT)
The thyroid gland lies
inferior to the larynx and requires iodine for hormone synthesis
The Thyroid Gland
Lies anterior to thyroid cartilage of larynx
Consists of two lobes connected by narrow isthmus
Thyroid follicles:
Hollow spheres lined by cuboidal epithelium
Cells surround follicle cavity that contains viscous colloid
Surrounded by network of capillaries that
deliver nutrients and regulatory hormones
accept secretory products and metabolic wastes
The Thyroid Gland
Thyroglobulin (Globular Protein)
Synthesized by follicle cells
Secreted into colloid of thyroid follicles
Molecules contain the amino acid tyrosine
Thyroxine (T4)
Also called tetraiodothyronine
Contains four iodide ions
Triiodothyronine (T3)
Contains three iodide ions
The Thyroid Gland
Figure 10-9a
The Thyroid Gland
Figure 10-9b
The Thyroid Gland
Thyroid-Stimulating Hormone (TSH)
Absence causes thyroid follicles to become inactive:
Neither synthesis nor secretion occurs
Binds to membrane receptors
Activates key enzymes in thyroid hormone production
The Thyroid Gland
Thyroid Hormones
Enter target cells by transport system
Affect most cells in body
Bind to receptors in:
Cytoplasm
Surfaces of mitochondria
Nucleus
In children, essential to normal development of:
Skeletal, muscular, and nervous systems
The Thyroid Gland
Calorigenic Effect
Cell consumes more energy resulting in increased heat generation
Is responsible for strong, immediate, and short-lived increase in rate of cellular metabolism
The Thyroid Gland
C (Clear) Cells of the Thyroid Gland
Produce calcitonin (CT):
Helps regulate concentrations of Ca2+ in body fluids
The four parathyroid
glands, embedded in the posterior surface of the thyroid gland, secrete parathyroid hormone to elevate blood calcium levels
Parathyroid Glands
Embedded in posterior surface of thyroid gland
Parathyroid hormone (PTH)
Produced by chief cells
In response to low concentrations of Ca2+
Figure 18–12
Parathyroid Glands
Figure 10-11
Parathyroid Glands
Four Effects of PTH
It stimulates osteoclasts:
Accelerates mineral turnover and releases Ca2+ from bone
It inhibits osteoblasts:
Reduces rate of calcium deposition in bone
It enhances reabsorption of Ca2+ at kidneys, reducing urinary loss
It stimulates formation and secretion of calcitriol at kidneys:
Effects complement or enhance PTH
Enhances Ca2+, PO43- absorption by digestive tract
Figure 18–12
Figure 10-10
The suprarenal glands,
consisting of a cortex and a
medulla, cap each kidney and
secrete several hormones
Suprarenal (Adrenal) Glands
Lie along superior border of each kidney
Subdivided into
Superficial suprarenal cortex:
Stores lipids, especially cholesterol and fatty acids
Manufactures steroid hormones: adrenocortical steroids (corticosteroids)
Inner suprarenal medulla:
Secretory activities controlled by sympathetic division of ANS
Produces epinephrine (adrenaline) and norepinephrine
Metabolic changes persist for several minutes
Suprarenal Glands
Mineralocorticoids
For example, aldosterone:
Stimulates conservation of sodium ions and elimination of potassium ions
Increases sensitivity of salt receptors in taste buds
Secretion responds to:
Drop in blood Na+, blood volume, or blood pressure
Rise in blood K+ concentration
Suprarenal Glands
Glucocorticoids
For example, cortisol (hydrocortisone) with corticosterone:
Liver converts cortisol to cortisone
Secretion regulated by negative feedback
Has inhibitory effect on production of
Corticotropin-releasing hormone (CRH) in hypothalamus
ACTH in adenohypophysis
Suprarenal Glands
Produces androgens under stimulation by ACTH
Suprarenal Glands
Figure 10-12
Suprarenal Glands
Suprarenal Medulla
Contains two types of secretory cells:
One produces epinephrine (adrenaline):
75% to 80% of medullary secretions
The other produces norepinephrine (noradrenaline):
20% to 25% of medullary secretions
The pineal gland, attached to the third ventricle, secretes melatonin
Pineal Gland
Lies in posterior portion of roof of third ventricle
Contains pinealocytes
Synthesize hormone melatonin
Pineal Gland
Functions of Melatonin
Inhibiting reproductive functions
Protecting against damage by free radicals
Setting circadian rhythms
The endocrine pancreas
produces insulin and glucagon, hormones that regulate blood glucose levels
Pancreas
Lies between
Inferior border of stomach
And proximal portion of small intestine
Contains exocrine and endocrine cells
Pancreas
Endocrine Pancreas
Consists of cells that form clusters known as pancreatic islets, or islets of Langerhans:
Alpha cells produce glucagon
Beta cells produce insulin
Pancreas
Figure 10-13
Pancreas
Blood Glucose Levels
When levels rise:
Beta cells secrete insulin, stimulating transport of glucose across plasma membranes
When levels decline:
Alpha cells release glucagon, stimulating glucose release by liver
Figure 10-14
Many organs have secondary endocrine functions
Endocrine Tissues of Other Systems
Intestines (digestive system)
Kidneys (urinary system)
Heart (cardiovascular system)
Thymus (lymphoid system and immunity)
Gonads (reproductive system)
Endocrine Tissues of Other Systems
Intestines
Produce hormones important to coordination of digestive activities
Kidneys
Produce the hormones calcitriol and erythropoietin
Produce the enzyme renin
Endocrine Tissues of Other Systems
Heart
Produces natriuretic peptides (ANP and BNP):
When blood volume becomes excessive
Action opposes angiotensin II
Resulting in reduction in blood volume and blood pressure
Thymus
Produces thymosins (blend of thymic hormones):
That help develop and maintain normal immune defenses
Endocrine Tissues of Other Systems
Testes (Gonads)
Produce androgens in interstitial cells:
Testosterone is the most important male hormone
Secrete inhibin in nurse (sustentacular) cells:
Support differentiation and physical maturation of sperm
Endocrine Tissues of Other Systems
Ovaries (Gonads)
Produce estrogens:
Principle estrogen is estradiol
After ovulation, follicle cells:
Reorganize into corpus luteum
Release estrogens and progestins, especially progesterone
Endocrine Tissues of Other Systems
Adipose Tissue Secretions
Leptin:
Feedback control for appetite
Controls normal levels of GnRH, gonadotropin synthesis
Resistin:
Reduces insulin sensitivity
Hormones interact
to produce coordinated
physiological responses
Hormone Interactions
Antagonistic (opposing) effects
Synergistic (additive) effects
Permissive effects: one hormone is necessary for another to produce effect
Integrative effects: hormones produce different and complementary results
Hormones and Growth
Growth Hormone (GH)
In children:
Supports muscular and skeletal development
In adults:
Maintains normal blood glucose concentrations
Mobilizes lipid reserves
Hormones and Growth
Thyroid Hormones
If absent during fetal development or for first year:
Nervous system fails to develop normally
Mental retardation results
If T4 concentrations decline before puberty:
Normal skeletal development will not continue
Hormones and Growth
Insulin
Allows passage of glucose and amino acids across plasma membranes
Parathyroid Hormone (PTH) and calcitriol
Promote absorption of calcium salts for deposition in bone
Inadequate levels cause weak and flexible bones
Hormones and Growth
Reproductive Hormones
Androgens in males, estrogens in females
Stimulate cell growth and differentiation in target tissues
Produce gender-related differences in:
Skeletal proportions
Secondary sex characteristics
Hormones and Stress
General Adaptation Syndrome (GAS)
Also called stress response
How body responds to stress-causing factors
Is divided into three phases:
Alarm phase
Resistance phase
Exhaustion phase
Figure 18–18
Hormones and Stress
Figure 10-15
Hormones and Stress
Figure 10-15
Hormones and Stress
Figure 10-15
Hormone Interactions
Hormones and Behavior
Can alter intellectual capabilities, memory, learning, and emotional states
Affect behavior when endocrine glands are over-secreting or under-secreting
Aging
Causes few functional changes
Decline in concentration of:
Growth hormone
Reproductive hormones
Extensive integration
occurs between the endocrine
system and other body systems
The Endocrine System
in Perspective
Functional Relationships Between
the Endocrine System and Other Systems
Copyright © 2010 Education, Inc.
The Integumentary System protects
superficial endocrine organs;
epidermis synthesizes vitamin D3
The Endocrine System’s sex
hormones stimulate sebaceous
glands, influence hair growth, fat
distribution, and apocrine sweat
glands; PRL stimulates development
of mammary glands; suprarenal
hormones alter dermal blood flow,
stimulate release of lipids from
adipocytes; MSH stimulates
melanocytes
The Integumentary System
Copyright © 2010 Education, Inc.
The Skeletal System protects
endocrine organs, especially in the
brain, chest, and pelvic cavity
The Endocrine System regulates
skeletal growth: PTH and calcitonin
mobilize calcium; sex hormones
speed growth and close epiphyseal
cartilages at puberty, and help
maintain bone mass in adults
The Skeletal System
Copyright © 2010 Education, Inc.
The Muscular System
The Muscular System provides
protection for some endocrine
organs
The Endocrine System adjusts
Muscle metabolism, energy
production, and growth; regulates
calcium and phosphate levels in
body fluids; speeds skeletal
muscle growth
Copyright © 2010 Education, Inc.
The Nervous System
The Nervous System’s hormones
control secretions by the pituitary,
other endocrine organs, and suprarenal
medullae; secretes ADH and oxytocin
The Endocrine System’s hormones
affect neural metabolism; help regulate
fluid and electrolyte balance;
reproductive hormones influence
CNS development and behaviors
Copyright © 2010 Education, Inc.
The Cardiovascular System
The Cardiovascular System’s
Vessels distribute hormones
throughout the body; heart secretes
ANP
The Endocrine System’s hormone
EPO regulates production of RBCs;
several hormones elevate blood
pressure; Epinephrine elevates heart
rate and contraction force
Copyright © 2010 Education, Inc.
The Lymphoid System
The Lymphoid System’s lymphocytes
defend against infection and, with
other WBCs, assist in repair after
Injury
The Endocrine System’s hormones
have anti-inflammatory effects
(glucocorticoids),
stimulate development of
lymphocytes (thymosins), and affect
immune function
Copyright © 2010 Education, Inc.
The Respiratory System
The Respiratory System provides
oxygen and eliminates carbon
Dioxide generated by endocrine
Cells
The Endocrine System’s
hormones Epinephrine and NE stimulate
respiration and dilate
respiratory passageways
Copyright © 2010 Education, Inc.
The Digestive System
The Digestive System provides
nutrients to endocrine cells; Pancreas
secretes insulin and glucagon; liver
produces angiotensinogen
The Endocrine System’s hormones Epinephrine and NE constrict sphincters and depress activity along digestive tract; digestive tract hormones coordinate secretions along tract
Copyright © 2010 Education, Inc.
The Urinary System
The Urinary System’s kidney cells
(1) release renin and EPO when local
blood pressure declines and
(2) produce calcitriol
The Endocrine System’s hormones
(aldosterone, ADH, and ANP) adjust
fluid and electrolyte reabsorption in
kidneys
Copyright © 2010 Education, Inc.
The Reproductive System
The Reproductive System’s steroid
sex hormones and inhibin suppress
secretion in hypothalamus and
pituitary
The Endocrine System’s hypothalamic
and pituitary hormones regulate
sexual development and function;
oxytocin stimulates contractions of
the uterus and mammary glands
Copyright © 2010 Education, Inc.
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