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SlideshowReport

Actions of mutM, mutT, and mutY gene products in countering the mutagenic effect of 8-oxoguanine -oG

Description

Depending upon the route of introduction of oG to DNA, the pathways shown can cause either GC ---> AT or AT ---> GC transversions.

MutT hydrolyzes 8-oxo-dGTP and prevents its incorporation during DNA replication.

MutM excises oG from a C-G base pair to begin BER.

MutY excises A from an A-oG base pair in another BER process, allowing an additional possibility for correcting an error in the next round of replication.
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