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SlideshowReport

Synthesis of the linear peptidoglycan molecule of S. aureus

Description
The peptidoglycan molecule is synthesized by addition of N-acetylglucosamine and five glycyl residues to N-acetylmuramylpentapeptide, with undecaprenol phosphate acting as carrier.

Sites of inhibition by the antibiotics bacitracin and vancomycin are identified.

Following synthesis, the peptidoglycan is transported through the cell membrane to the cell wall and added to the end of a chain in the peptidoglycan layer.
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