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SlideshowReport

Structure of the proteasome

Description
The proteasome contains two major assemblies, a 28-subunit core particle (aka the 20S particle) and a 19-subunit regulatory particle (aka the 19S particle), which forms the base and lid assemblies.

The proteolytic active sites are located within the large internal space (~100 x 60Å) of the 20S core particle.

The lid and base assemblies of the 19S regulatory particle control substrate entry into the 20S core particle.

Proteins tagged with the protein ubiquitin pass through the tube in an ATP-dependent fashion.
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