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Action of the DNA uracil repair system

Description
Uracil-DNA N-glycosylase (also called Ung) removes uracil, leaving an apyrimidinic site.

A specific endonuclease recognizes this 5’ site and cleaves on the side.

DNA polymerase I replaces the missing nucleotide, leaving deoxyribose-5-phosphate on the 5’ side of the nick.

This is removed hydrolytically, and DNA ligase seals the nick.
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