Examples of Autoantibodies Associated with Autoimmune Disorders

Table 37.4 Examples of Autoantibodies Associated With Autoimmune Disorders Disorder Crohn's disease Dermatomyositis Diabetes mellitus type 1 Goodpasture's syndrome Graves' disease GuillainiBarre syndrome Hashimoto’s disease Idiopathic thromboV cytopenic purpura Lupus ery‘thematosus Multiple sclerosis Myasthenia gravis Pemphigus vulgaris Pernicious anemia Polymyositis Primary biliary cirrhosis Rheumatoid arthritis Scleroderma Ulcerative colitis Wegener's granulomatosis Autoantibody Target Neutrophil granule proteins tRNA synthesis enzyme Islet proteins or insulin Type lV collagen TSH receptor Lipids of ganglia TH synthesis proteins Platelet glycoproteins DNA, nuclear proteins Myelin proteins Acetylcholine receptors Cadherin Parietal cell glycoprotein tRNA synthesis enzyme Nuclear pore proteins, mitochondria Constant region of lgG Topoisomerase Enzyme in neutrophil granules Enzyme in neutrophil granules Affected Area Gastrointestinal tract Muscles, skin Pancreas Kidney, lung Thyroid Peripheral nervous system Thyroid Blood (platelets) Connective tissue Central nervous system Neuromuscular junctions Skin Stomach epithelium Muscles Liver Joints Arteriole endothelium Large intestine Blood vessels