Stretch Activated Channels

Slielch-acllvaled channels can be opened la) by lhe stretch of the cell membrane itseli, (b) by the displacemenl oi cytoskeletal elements or (cedi by interacting with proteins inside and outside the neuron, which can sense defolmallon (modified from Del Valle et al., 2012). let A deactivated voltage-gated Na‘ channel ion channels have a selectivity filter, which makes them permeable only to certain Ions (In this case. Na‘ ionst Voltage-galed channeu also have voltage sensors (whlle rectangles with plus signst it) Depolarization ot the membrane «or example, from resting membrane potential to lhe threshold) is detected by the voltage sensors, causing the channel to open. and Na‘ enters the neuron. lg) An inactivation gate then closes the channels until the channel is once again deactivated oa" ea ° . , Inactivation ate Dsacllvaled a " a (closed) Na. ”MM inactivated (open) (closed)