Mutation analysis of the -globin gene promoter

Mutation analysis of the -globin gene promoter. The bars indicate that mutations in regions containing TATA box, CAAT box, and upstream GC-rich box sequences substantially reduce the relative transcription level. Orange dots indicate sites where no mutations were made and for which no data are availableMutation analysis of the -globin gene promoter. The bars indicate that mutations in regions containing TATA box, CAAT box, and upstream GC-rich box sequences substantially reduce the relative transcription level. Orange dots indicate sites where no mutations were made and for which no data are available

4.0 1.0 Relative transcription level -100 -80 -60 —40 -20 +1 20 : u -. ~ g ‘ man A c 5 A L3 GC—rich CAAT box '37 TATA box Transcription start (+1)