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Softball612 Softball612
wrote...
Posts: 494
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6 years ago
Describe how the lymphocyte development in the thymus minimizes T cells capable of
  inducing autoimmunity while maintaining T cells capable of recognizing foreign
  antigens.
 
  What will be an ideal response
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wrote...
6 years ago
Immature T cells in the thymus undergo two selection processespositive and negative. First, in order to react to
foreign antigen, T cells must be able to bind to the foreign antigen presented in conjunction with MHC antigens on
antigen presenting cells. In positive selection, only T cells capable of binding to MHC can bind to MHC in the
thymus live. Cells without the capability of binding to MHC do not bind to the appropriate cells and die by
apoptosis. Second, T cells that have receptors for self-antigens must not be allowed to live. T cells that react to
self-antigens in the thymus in conjunction with MHC are eliminated. Thus, the only T cells remaining should react
with MHC and any non-self antigens presented with it.
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