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Home Q & A Board Biology-Related Homework Help Medicine Immunology
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meaganec meaganec
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6 years ago
A helper T cell response to a protein antigen requires the participation of antigen-presenting cells that express which of the following types of molecules?
 
  A. Class II MHC and costimulators
  B. Class I MHC and CD4
  C. Class II MHC and CD8
  D. CD4 and costimulators
  E. Class II MHC and CD4
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#1
6 years ago
ANS: A. Helper T cells are almost always CD4+. The activation of naive CD4+ T cells requires T cell receptor recognition of class II MHC-peptide complexes and the binding of costimulators, both on the antigen-presenting cell (APC) surface. CD4+ helper T cells bind to class II MHC molecules on the APC, not to class I MHC molecules. CD4 or CD8 expression on the APC surface is of no known relevance to T cell activation.
meaganec Author
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#2
6 years ago
Words can't even express my thanks
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