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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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convivium convivium
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10 years ago
Would some kindly explain RNA interference?

What applications RNA interference be particularly useful for treatment of disease or drug delivery?

Who or which companies are focusing efforts on RNA interference?

Any ideas relating to challenges these researchers face with RNA interference?

I would really appreciate any help the forum can provide.

Thank you.

 
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Staff Member
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10 years ago
RNA interference is when the life span of an mRNA is controlled by tiny single stranded RNA molecules that bind to complementary sequences in the mRNA. Once part of an mRNA becomes double stranded in this way, specific proteins degrade the mRNA or prevent it from being translated into a polypeptide.

siRNA is a short double-stranded RNA, whose strands can complement and inactivate a sequence of mRNA.  miRNA is used to describe the full length of RNA transcripts synthesized form specific miRNA-coding genes.  miRNA becomes siRNA or miRNA when it is cleaved into smaller pieces.
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