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amer157 amer157
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12 years ago
A scientist creates a substance that denatures the enzyme DNA ligase. What impact will this substance have on the cell cycle? Explain.
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how_mendelhow_mendel
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12 years ago
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#2
12 years ago
DNA ligase is the key part in building DNA molecules, therefore destroying or "denaturing" these enzymes will clearly have a devastating impact on the cell cycle, ie. immense amount of mutations
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#3
12 years ago
This would interfere with DNA replication during S phase. DNA ligase is responsible for sealing the nicks between Okazaki fragments during DNA replication. Without ligase, the nicks do not seal and replication can not be successfully completed.
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#4
12 years ago
Yes, in short the discontinuous strand will remain as Okazaki fragments.
angie19
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#5
12 years ago
I would say that if the DNA ligase is desactivated, cell cycle will be stop, and cell will die.

DNA ligase is used to ligate the okazaki fragment (which are DNA fragment which contains a little sequence of RNA) together on the lagging strand. If these fragment are not ligate together, DNA molecule will be divide in different part, and genetic information will not be read correctly, or finally not read at all !
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#6
3 years ago
thank you
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#7
3 years ago
thank you!
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