× Didn't find what you were looking for? Ask a question
Top Posters
Since Sunday
New Topic  
heathtalon heathtalon
wrote...
Posts: 2
Rep: 0 0
10 years ago
The ABO and MN blood groups are given below for four sets of parents (1 to 4) and four children (a to d). Recall that the ABO blood group has three alleles, IA, IB, and i. The MN blood group has two codominant alleles, M and N.

Using your knowledge of these genetic systems, match each child with every set of parents who might have conceived the child, and exclude any parental set that could not have conceived the child.

Source  Genetic Analysis and integrated approach by Sanders/Bowman
 Attached file 
Thumbnail(s):
You must login or register to gain access to this attachment.
Read 5973 times
5 Replies

Related Topics

Replies
wrote...
Donated
Valued Member
10 years ago
The statement:
"Recall that the ABO blood group has three alleles, IA, IB, and i. The MN blood group has two codominant alleles, M and N."
is very helpful.

We should be able to deduce:
In the ABO typing system,
Type A is iAiA or iAi
Type B is iBiB or iBi
Type AB is iAiB only
Type O is ii only

In the MN typing system,
Type M is MM only
Type MN is MN only
Type N is NN only

Let's use this information:
Mother1: ii; MM only
Father1: iBiB or iBi; MM only
Mother 2: iBiB or iBi; NN only
Father 2: iBiB or iBi; NN only
Mother 3: iAiB; MN only
Father 3: iBiB or iBi; MN only
Mother 4: iAiA or iAi; NN only
Father 4: iBiB or iBi; MN only

Remember that each parent donates one allele from each blood typing.

Child a (B; M):
iBiB or iBi; MM only
Parents 1 are included.  Mother 1 donates i; M and Father 1 donates iB; M
Parents 2 are excluded.  While they could have accounted for the ABO blood type, two N parents will have all N children (NN x NN = all NN)
Parents 3 are included.  Mother 3 donates iB; M and Father 3 donates iB; M
Parents 4 are excluded.  While they could have accounted for the ABO blood type, an N parent and an MN parent will have only N and MN children (NN x MN = NN or MN)

Child b (O; M):
ii only; MM only
Parents 1 are included.  Mother 1 donates i; M and Father 1 donates i (remember he can be iBi or iBiB); M
Parents 2 are excluded.  While they could have accounted for the ABO blood type, two N parents will have all N children (NN x NN = all NN)
Parents 3 are excluded.  Mother 3 is iAiB.  She can only produce A, B, or AB offspring.
Parents 4 are excluded.  While they could have accounted for the ABO blood type, an N parent and an MN parent will have only N and MN children (NN x MN = NN or MN).

Child c (AB, MN):
iAiB; MN
Parents 1 are excluded.  Neither has an iA allele.
Parents 2 are excluded.  Neither has an iA allele.
Parents 3 are included.  Mother 3 donates an iA and M or N.  Father 3 donates an iB and the M or N (the opposite of the mother's MN allele).
Parents 4 are included.  Mother 4 donates iA; N.  Father 4 donates iB; M.

Child d (B, N):
iBiB or iBi; NN only
Parents 1 are excluded.  While they could have accounted for the ABO blood type, two M parents will have all M children (MM x MM = all MM)
Parents 2 are included.  Both mother 2 and father 2 could have donated either i or iB (as long as one or both parents donates an iB, as ii would be an O offspring);N
Parents 3 are included.  Mother 3 donates iB; N and Father 3 donates either iB or i;N.
Parents 4 are included.  Mother 4 donates i;N.  Father 4 donates iB;N.

I hope this all makes sense.  I tried to make it as verbose as possible so you could learn from it.
Pretty fly for a SciGuy
wrote...
10 years ago
1=b : 2=d : 3=c : 4=a

Couple 1: ii MM x IBi MM
Possible children: IBi MM or ii MM -- B,M or O,M

Couple 2: IBi NN x IBi NN
Possible children: IBIB NN or IBi NN; ii NN -- B,N or O,N

Couple 3: IAIB MN x IBi MN
Possible children: IAIB; IAi; IBi; (with MM or MN or NN) -- AB,M; AB,MN; AB,N; AM; A,MN; A,N; B,M; B,MN; B,N

Couple 4: IAi NN x IBi MN
Possible children: IAIB, IAi, IBi, ii (MN or NN) -- AB,MN; AB,N; A,MN; A,N; B,MN; B,N; O,MN; O,N

Children a-d:
a: B,M - could be from couple 1 or 3
b: O,M - could be from couple 1 only
c: AB,MN - could be from couple 3 or 4
d: B,N - could be from couple 2 or 4

By process of elimination:
Couple 1: b
Couple 2: a
Couple 3: c
Couple 4: d
wrote...
Donated
Valued Member
10 years ago
That answer is incorrect.  Couple 3 could also be the parents of child d. (AB;MN x B;MN = BN from iB;N maternal and iB;N paternal = iBiB;NN (child d)).

Also, from the way the question is worded, the purpose is not to pair the parents to children but to state all possibilities and exclusions.  Given this new piece of information, however, assuming that the question wants an actual pairing, the correct pairing would be:

Children a-d:
a: B,M - could be from couple 1 or 3
b: O,M - could be from couple 1 only
c: AB,MN - could be from couple 3 or 4
d: B,N - could be from couple 2, 3, or 4

By process of elimination:
Couple 1: b
Couple 2: d
Couple 3: a
Couple 4: c


Steps to this conclusion:
b can be 1 only, therefore we can eliminate 1 from a and deduce that a is 3.  We can then eliminate 3 from c and d, and therefore, only 4 can be c and this leaves 2 for d.

Still think that's more logic than genetics, though.  This assumes that these are the only possible parents and children (not explicitly stated).  I think the inclusion/exclusion statements are the best answer.
Pretty fly for a SciGuy
wrote...
3 years ago
thanks
wrote...
7 months ago
Thx
New Topic      
Explore
Post your homework questions and get free online help from our incredible volunteers
  1235 People Browsing
Related Images
  
 332
  
 70
  
 578
Your Opinion
Which industry do you think artificial intelligence (AI) will impact the most?
Votes: 352