hey :-) following the next table
36 81 93 177 342 402 714
Human 1 GUA ACC GUA AUA CCG AGC CGG
Human 2 GCA ACC GUU AUA CCA AGC CGG
Human 3 GUA ACA GUA AUG CCA AGC CGA
Human 4 GUA ACA GUA AUG CCA AGU CGA
1. the all synonymous locus is 3000 , in the table theirs 4 synonymous codes from the 3000 synonymous sites in the locus . if we know that the rate of the mutation Per generation is - u=2*10^-8 what is the effective size of the population (Ne) ? (Assume that the population support the Wright fisher model without selection for population in Equilibrium - and use the formula of Heterozygous that is expected in this case ? )
2. Turns out that the 2 first individuals above the table are from Africa whereas the rest 2 is from Asia: calculate the Heterozygous between the 2 African individuals (H within ). And calculate the H between - and from there calculate The Fst , when Fst= ((H between-H within))/H(between) .
3.ignoring the stochastic that involve in the model that we see , if its logical that the individual that were measure , there from panmictic population ?
4. Use the same methods that you activated on the sequence information in different species to deduce now from the information of the sequence within the same species; what is the time until the predecessor of the 2 African individuals? , in the assumption that the duration of generation in human is 20 years ?
tanks!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
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