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Home Q & A Board Biology-Related Homework Help Biochemistry
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mikael mikael
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10 years ago
In strenuously working muscle the pH decreases. This inhibits the activity of PFK-1 and glycolysis slows. Why would it be desirable to slow glycolysis when the demand for ATP is high?
A) Inhibition of PFK-1 allows for the complete oxidation of pyruvate via the citric acid cycle.
B) Slowing glycolysis slows the rate of decrease in pH. A low pH can be harmful and potentially fatal.
C) The less active form of PFK-1 is a potent allosteric activator of creatine, so even though glycolysis is slowed, ATP production is actually increased by the activation of creatine.
D) As PFK-1 is inhibited, its isozyme, PFK-2 is activated. PFK-2 is functional at a much lower pH than PFK-1.
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padrepadre
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10 years ago
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mikael Author
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10 years ago
Thanks Padre
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