A middle-aged male is taking pseudoephedrine (Sudafed) for nasal congestion. What adverse effect is ...

Correct Answer: 2
Rationale 1: Uric acid levels are not affected by decongestants.
Rationale 2: Decongestants bind to alpha-1-adrenergic receptors. This can cause changes in the urethra with urinary retention in a male with preexisting narrowing from an enlarged prostate.
Rationale 3: Incontinence of urine is very unlikely.
Rationale 4: Serum creatine levels are not affected by decongestants.
Global Rationale: Alpha-adrenergic agonists should be used with caution in patients with prostatic enlargement, because these drugs increase smooth muscle activity in the prostate gland and may diminish urinary outflow. Uric acid and serum creatine levels are not affected and incontinence is unlikely.